1
Unique InChIKey
100
Unique Receptor Sequence
4
Unique Co-Receptor Sequence
1
EC50 Parameter
8
Unique DOI
Results
Showing 1 to 30 of 138 results
| Receptor | Co-Receptor | Molecule | Response | Bioassay | Resources | |||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | Or22a | P81909 | - | MLSKFFPHIKEKPLSERVKSRDAFIYLDRV ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... |
Isovaleric Acid
3-Methylbutanoic acid |
503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Dose-Response | N.A. | EC50 | N.A. | 11 | Calcium Imaging | Olympus BX50WI | ∆ Fluorescence | Drosophila | wild-type OSN | endogenous promoter | Head Space | 1 mL/s | 1 mL/s | 2 s | Pelz, D., Roeske, T., Syed, Z. ... | 10.1002/neu.20333 | Table 2 |
| Apis mellifera | Or136 | A0A7M7M5T4 | - | MNVFDKHYHTYRTLMKIVGLWPYNNSIYVW ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 1.25 Spikes/s | Norm. other | 100 µg/µL | 11 | Single Sensillum Recording | tungsten electrode | Spiking Frequency | Drosophila | ab3A | N.A. | Airborne Paper | 500 mL/min | 3 L/min | 1 s | Andreu, B., Mariette, J., Dela ... | 10.1038/s42003-025-09391-z | Fig2+ Annex1b |
| Apis mellifera | Or109 | A0A7M6UWX9 | - | MDERAIEDQYLKINKFFGQLVGVWPYQKKF ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... |
Isovaleric Acid
3-Methylbutanoic acid |
503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0.722 Spikes/s | Norm. other | 100 µg/µL | 10 | Single Sensillum Recording | tungsten electrode | Spiking Frequency | Drosophila | ab3A | N.A. | Airborne Paper | 500 mL/min | 3 L/min | 1 s | Andreu, B., Mariette, J., Dela ... | 10.1038/s42003-025-09391-z | Fig2+ Annex1a |
| Anopheles gambiae | Or1 | Q8WTE7 | - | MKLNKLNPRWDAYDRRDSFWLQLLCLKYLG ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 2 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or2 | Q8WTE6 | - | MLIEECPIIGVNVRVWLFWSYLRRPRLSRF ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -1.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or3 | Q8WTE4 | - | MPSERLRLITSFGTPQDKRTMVLPKLKDET ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 5.067 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or4 | Q7PMZ4 | - | MKFELFQKYSSPDTVLSFVLRLLHIVGMNG ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 10 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or5 | Q7Q337 | - | MVLPKLSEPYAVMPLLLRLQRFVGLWGERR ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 2.867 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or6 | Q7PIE7 | - | MVRLSFEETLRNTNLMLLMMGIPPCEEPYP ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -0.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or8 | Q7PUT5 | - | MDPPTDELVRFESFIRVPEIFFAMIGVARY ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -2 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or9 | Q7PN78 | - | MVRLFFSKTRVTKLFTRKDERPEMFLPSLR ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -6.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or10 | Q7QG60 | - | MEVLNCPLLSVNVRVWRFWSFVLVHNWRRY ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 4 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or11 | Q7PV18 | - | MELKEEWILPDVVYANPLLKRTLLGLRYYG ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 4 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or12 | A0NC62 | - | MEKLRPEDPKAVMPYAKRLLQLSGFRQDTE ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -1.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or13 | Q7PSD5 | - | MNFLRQEQPAGMPHISIKLLQLFGVTGSPE ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 1.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or15 | Q7PSD7 | - | MNFLRQEQPAGMPHISIKLLRVFGVTNHSE ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or16 | Q7PSF0 | - | MRFFLIEKPPGVPHIALKLLRLVGVSQTQS ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0.733 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or18 | Q7QGB2 | - | MTSFKPTDDTDVMPLVLRLLRVIGVWDVPQ ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -2.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or20 | A0A1S4H1W2 | - | MLRLSPEDPKAVMPVVKRLLKLSGLTQETT ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 20 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or21 | Q7PSF3 | - | MLRLSPEDPKAVMPFAKRLLRLSGFRQETE ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 2 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or23 | Q7PIY7 | - | MRWRKDETGLHTPQCTVDLPGDGSHSVSVR ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or25 | Q7PGS4 | - | MEQEINQIISFLRRPLKWLGFDVIDPNWKV ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -1.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or26 | Q7PHE7 | - | MDSNSKKDTFPLIQISTKMLQIIRLWNESS ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or27 | Q7PQB6 | - | MKPSCKEGVFPLINLSIKLLKIVGFWSKTT ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 13 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or30 | Q7PFK7 | - | MKFFQIDDTREILPIGCRLLMLCGLPRSGR ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 10 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or31 | Q7PPH3 | A355_I356ins[5 aa] | MLAAETVDFFRVQSICLRAIGIARTDSFRG ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 3.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or32 | Q7PPG6 | - | MSQLNEFPAYQFRLIRFCGVVEQPSLRNNV ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 12 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or35 | Q7PPH4 | - | MSCVEDFLDAQMWYLRYCGVFREKSALGGI ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 0.667 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or39 | Q7PRB0 | - | MVSFGAAASNPRDAETTPHWDIFKLQRKIL ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | 5 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |
| Anopheles gambiae | Or41 | Q7PFY5 | - | MSEHPIHTFDRLIKRQRLLLKLIGIDSYDP ... | Drosophila melanogaster | Orco | Q9VNB5 | - | MTTSMQPSKYTGLVADLMPNIRAMKYSGLF ... | Isovaleric Acid | 503-74-2 | GWYFCOCPABKNJV-UHFFFAOYSA-N | 10430 | CC(C)CC(=O)O | Monomolecular | No | Primary | -1.333 Spikes/s | Norm. receptor | 0.01 V/V | 5-6 | Single Sensillum Recording | N.A. | Spiking Frequency | Drosophila | N.A. | pUAS | Airstream | 3.2 mL/s | 32 mL/s | 500 ms | Carey, A. F., Wang, G., Su, C. ... | 10.1038/nature08834 | |